Rosanna, a former Miss World winner, looked forward to starting a family after getting married. But reality was far from what she imagined. Over the course of three years, she experienced 14 pregnancy losses. Each pregnancy brought renewed hope, only to end within a short time. Doctors later explained that, in some cases, a woman's immune system may recognize the embryo as an "abnormal signal," making it difficult to maintain the pregnancy. After repeated heartbreak, Rosanna and her husband ultimately chose surrogacy. With the help of a surrogate in Ukraine, they finally welcomed their daughter, Sophia.

What Is a Missed Miscarriage?

A missed miscarriage occurs when an embryo stops developing during early pregnancy. It is not the same as a typical miscarriage, nor is it simply a matter of bad luck. When pregnancy loss happens repeatedly, further investigation is usually needed. Embryo quality, the uterine environment, endocrine balance, blood clotting disorders, immune factors, and the quality of both sperm and eggs can all affect whether a pregnancy progresses normally.

Why Do Recurrent Pregnancy Losses Happen?

The most common causes of recurrent pregnancy loss include chromosomal abnormalities, immune-related conditions, uterine abnormalities, and hormonal disorders. As maternal age increases, the likelihood of chromosomal abnormalities in embryos also rises, making this one of the leading causes seen in clinical practice. Some individuals are still able to conceive, but declining egg quality makes it difficult to sustain a healthy pregnancy.

Immune-related factors are another issue that is often overlooked. Although the immune system is designed to protect the body, in certain cases it may interfere with embryo implantation or early fetal development. These conditions usually require comprehensive evaluation rather than routine examinations alone.

Why Embryo Screening Matters

Modern assisted reproductive technology typically cultures fertilized embryos to the blastocyst stage before performing IVF-PGT. By identifying embryos with stronger developmental potential, IVF-PGT can improve overall pregnancy outcomes while reducing the risk of miscarriage caused by chromosomal abnormalities.

What Can Be Done After Recurrent Pregnancy Loss?

After experiencing multiple pregnancy losses, repeated attempts alone are often not the best approach. A comprehensive evaluation is recommended, including parental chromosome analysis, immune-related testing, uterine assessment, endocrine evaluation, and, when appropriate, embryonic genetic analysis to better understand the underlying cause.

Some families are able to continue trying naturally or through assisted reproductive treatment after targeted management. Others may achieve better outcomes by combining fertility treatment with surrogacy. The most appropriate plan should always be based on each family's individual medical circumstances rather than a one-size-fits-all approach.

Power Fertility Clinic is a fully licensed fertility center in Mexico operating under U.S. FDA standards and managed by a U.S.-based reproductive medicine team. Located in the heart of Mexico City, just 500 meters from the U.S. Embassy, Power IVF offers comprehensive fertility solutions, including egg donation, sperm donation, and surrogacy, combined with advanced U.S. IVF technology to support intended parents of all ages. The clinic features a state-of-the-art laboratory specializing in IVF-PGT (PGT-A) and embryo screening, helping improve treatment outcomes. Mexican regulations support IVF treatment for single individuals, married couples, and LGBTQ families, while also allowing the international transport of frozen reproductive tissues. Power IVF is licensed to receive frozen eggs from the United States, making cross-border fertility care more accessible.